Fibrocystic Breast Disease | HealthmadFibrocystic Breast Disease is experienced by as many as 80% of women. The symptoms are painful lumps in the breasts before the monthly menstrual cycle. Some doctors say it isn’t really a disease since it’s common to so many women. Other doctors disagree and say women who have this condition should have tests to rule out cancer. Hormonal changes and an imbalance of estrogen over progesterone is thought to be the cause of fibrocystic breast disease.